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Pazopanib was previously known as GW786034 & produced by Glaxo Smith Kline

Renal cell carcinoma (second line metastatic) - pazopanib Pazopanib for the second line treatment of metastatic renal cell carcinoma

Status: In progress Expected date of issue: January 2011 Wave: CRS1 Process: STA Notes: Cancer reform strategy Batch 1

Topic area: Cancer Urogenital

Project team | Schedule | Stakeholders | Key documents

NICE project team Executive lead: TBC Technical lead: TBC Communications manager: TBC Project manager: Christopher Feinmann Top

Provisional schedule Closing date for evidence submission: 13 May 2010 First appraisal committee meeting: 11 August 2010


The Mechanism of Action is as an Angiogenesis inhibitor, VEGF1, VEGF2, VEGF3, c-KIT, PDGFR beta

Aimed to Target VEGFRs, c-KIT, PDGFR beta

For Classes - Small Molecule

MOA Classes - Angiogenesis inhibitor/split kinase

About Pazopanib

Pazopanib is an investigational, oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and c-kit. Pazopanib is currently in Phase III development for the treatment of advanced or metastatic RCC, after completing patient enrollment several months ahead of schedule, and is also being studied in a number of other trials across various tumor types.

Safety considerations

In more than 1000 patients treated to date with Pazopanib in clinical trials, serious but uncommon (<1%) reports of bowel perforation, myocardial infarction/angina and cerebrovascular accidents/transient ischemic attacks have been reported. The most common laboratory abnormality was an elevation in liver transaminase which occurred as an asymptomatic, reversible event.

Fact Sheet from Glaxo Smith Kline


Click here for 2009 Articles

MedicalNewsToday (KC) 11-Jun-07


Clinical Trials have been ongoing in the UK over the past 2 years. entry now closed, full results awaited.


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