VEGF

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Contents

Overview

Vascular Endothelial Growth Factor (VEGF)

VEGF is a key driver of angiogenesis - the formation of new blood vessels. By inhibiting VEGF receptors, drugs such as Recentin (AZD-2171) hinders angiogenesis, thus preventing the blood supply that Tumours need to grow and spread. There are three VEGF receptors involved in Tumour angiogenesis:

VEGFR-1

VEGFR-2

VEGFR-3

Recentin inhibits all three, 1 in particular VEGFR-2, the predominant receptor through which VEGF exerts its effect on angiogenesis.

Articles

Aveo (KC) 14-Apr-08

  • AVEO Pharmaceuticals’ Novel Triple VEGF Receptor Inhibitor Shows Tumor Regression in Patients with Advanced Renal Cancer; Clinical Activity and Tolerability in other Solid Tumors including Colon and Lung Cancers

References

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