From Kidney Cancer Resource

Jump to: navigation, search



AS1411 is a cancer drug produced by Antisoma



AS1411 has shown activity against a wide range of solid and blood cancer cell lines in preclinical experiments and could therefore have potential against a variety of human cancers. Initial clinical development is focused on one blood cancer, AML (acute myeloid leukaemia) and one solid tumour, renal cancer (kidney cancer or renal cell carcinoma). A phase II clinical trial is ongoing in AML and a phase II trial is planned in renal cancer.

A previous phase I trial of AS1411 in 30 patients with various advanced cancers reported no serious adverse events related to treatment. Promising signs of anti-cancer activity were seen among patients in the trial with renal cancer (see below).

AS1411 is an aptamer. This is a type of drug based on a short piece of DNA or RNA. However, unlike some other drugs based on these chemicals, aptamers work as conventional drugs, binding to a protein target by virtue of a fit with its three-dimensional structure. The term aptamer is derived from the Greek ‘aptos’ (to fit).

AS1411 has a structure that allows it to bind specifically to a protein called nucleolin, which is found on the surface of many cancer cells. One bound, the AS1411 aptamer is taken into the cancer cell, where it causes death by apoptosis (programmed cell death).

Renal cancer

In the phase I trial of AS1411 there were 12 patients with advanced renal cancer. Promising signs of anti-tumour activity were seen in this group, including two objective responses with substantial tumour shrinkage. In addition to these clinical findings, renal cancer cell lines have shown high sensitivity to AS1411. We are planning to start a phase II trial in renal cancer in 2008.

To view the original of this article Click Here


Earth Times (KC) 05-Sep-08


Convert This Page to PDF format

Was this information useful? ( 0 votes )


Kidney Cancer Resource (KCR) is not influenced by sponsors. The information contained herein is not intended as a substitute for the advice of an appropriately qualified and licensed physician or other licensed health care provider. The information provided here is for educational and information purposes only. Early accurate Diagnosis (Dx.) saves lives. Please check with a physician if you suspect you are ill, never ignore Symptoms. To help your health care specialist make an accurate Diagnosis please keep notes of dates, times and details of your Symptoms. We are not offering medical advice nor do we consider links, individuals or articles accessed through this site to be offering medical advice.

E&OE - Errors & Omissions Excepted

As much of the information posted on this Web Site for peoples convenience is of a medical or technical nature, and may be a matter of life or death the E&OE is a Disclaimer showing that to the best of our ability information is accurate and correctly written or transcribed. Before acting on information on this site you are responsible for checking it with your relevant medical team. We can not be held responsible for any Errors & Omissions made; nor for information on links and articles provided in good faith.

Personal tools
Locations of visitors to this page